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Patents

Patents

  1. Guasch, J.; Ratera, I.; Veciana, J.; Santos, F.; Pérez del Río, E.; Castellote-Borrell, M. Inverse opal hydrogel and its use. EPO (EP22382293.3). Priority date 29/03/2022.
  2. Guasch, J.; Ratera, I.; Veciana, J.; Pérez del Río, E.; Santos, F.; Miguel, M. M.; Rodriguez, X. R.; Timoneda, M. Á. M.; Engel, E. A synthetic hydrogel and its use for immunotherapy and 3D-printing. PCT application (WO2021/234141 A1). Priority date 21/05/2020.

Read more …Patents

Publications

  • 2024

40. Migration of human T cells can be differentially directed by electric fields depending on the extracellular microenvironment
 Ende K., Santos F., Guasch J., Kemkemer R. iScience 2024, accepted.

39. pH-Sensitive Acrylic Terpolymers for the Coating of Orally Administered Drugs Used for Colonic Release
Suárez L.M., Hoyos L., Castellote-Borrell M., Guasch J., Orozco V.H., Giraldo L.F. ACS Omega 2024, 9(1), 204.

  • 2023

    38. 3D cell culture of CAR T cells originated from peripheral blood mononuclear cells towards cellular therapies
    Pérez del Río E., Román Alonso M., Rius I., Santos F., Castellote-Borrell M., Veciana J., Ratera I., Arribas J., Guasch J. Cytotherapy 2023, 25(12), 1293.

    37. Biohybrid synthetic hydrogels for tumoroid culture
    Castellote-Borrell M., Merlina F., Rodríguez A.R., Guasch J. Adv. Biol. 2023, 2300118.

    36. Ratiometric Nanothermometer Based on a Radical Excimer for In Vivo Sensing
    Blasi D., Gonzalez-Pato N., Rodriguez X.R., Diez-Zabala I., Srinivasan S.Y., Camarero N., Esquivias O., Roldán M., Guasch J., Laromaine A., Gorostiza P., Veciana J., Ratera I. Small 2023, 19, 2207806.

    35. Antibiofilm surfaces based on the immobilization of a novel recombinant antimicrobial multidomain protein using self-assembly monolayers
    Kyvik A.R., Roca R., Mayolo-Deloisa K., Rodriguez X.R., Martínez-Miguel M., Martos M., Köber M., Ventosa N., Veciana J., Guasch J., Garcia-Fruitós E., Arís A.P., Ratera I. Mater. Adv. 2023, 4, 2354.

    34. A Novel Generation of Tailored Antimicrobial Drugs Based on Recombinant Multidomain Proteins
    López-Cano A., Ferrer-Miralles N., Sánchez J., Carratalá J.V., Rodriguez X.R., Ratera I., Guasch J., Pich O.Q., Bierge P., Garcia-de-la-Maria C., Miro J.M., Garcia-Fruitós E., Arís A.P. Pharmaceutics 2023, 15(4), 1068.

    33. Electroactive substrates for surface-enhanced Raman spectroscopy based on overgrown gold-nanoparticle arrays by electrodeposition on indium tin oxide
    González-Pato, N.; Rodriguez, X. R.; Pellizi, N.; Fasolato, C.; Guasch, J.; Postorino, P; Veciana, J.; Goñi, A. R.; Ratera, I. Mater. Adv. 2023, 4, 1378.

  • 2022

    32. Hierarchical Quatsome-RGD Nanoarchitectonic Surfaces for Enhanced Integrin-Mediated Cell Adhesion
    Martínez-Miguel, M.; Castellote-Borrell, M.; Köber, M.; Kyvik, A. R.; Tomsen-Melero, J.; Vargas-Nadal, G.; Muñoz, J.; Pulido, D.; Cristóbal-Lecina, E.; Passemard, S.; Royo, M.; Mas-Torrent, M.; Veciana, J.; Giannotti, M. I.; Guasch, J.; Ventosa, N.; Ratera, I., ACS Appl. Mater. Interfaces, 2022, 14(42), 48179.

    31. Enhanced human T cell expansion with inverse opal hydrogels
    Santos F.; Valderas-Gutiérrez, J.; Pérez del Río E.; Castellote-Borrell, M; Rodriguez Rodriguez, X.; Veciana, J.; Ratera, I.; Guasch, J. Biomater. Sci., 2022, 10, 3730.

    30. Exploring the impact of the recombinant Escherichia coli strain on defensins antimicrobial activity: BL21 versus Origami strain
    López-Cano A.; Martínez-Miguel, M.; Guasch, J.; Ratera, I.; Arís A.; Garcia-Fruitós E. Microb. Cell Factories, 2022, 21, 77.

    29. Methods for the Characterization of Protein Aggregates
    Martínez-Miguel, M.; Tatkiewicz, W.; Köber, M.; Veciana, J.; Ventosa N. ; Guasch, J.; Ratera, I. Methods in Molecular Biology 2022, 2406, 479. (book chapter)

    28. Methods for Processing Protein Aggregates into Surfaces
    Martínez-Miguel, M.; Tatkiewicz, W.; Köber, M.; Veciana, J.; Ventosa N. ; Guasch, J.; Ratera, I. Methods in Molecular Biology 2022, 2406, 517. (book chapter)

  • 2021

    27. Polylactide, Processed by a Foaming Method Using Compressed Freon R134a, for Tissue Engineering
    Aguado, M.; Saldaña, L.; Pérez del Río, E.; Guasch, J.; Parera, M.; Córdoba, A.; Seras-Franzoso, J.; Cano-Garrido, O.; Vázquez, E.; Villaverde, A.; Veciana, J.; Ratera, I.; Vilaboa, N.; Ventosa N. Polymers 2021, 13(20), 3453.

  • 2020

    1. CCL21-loaded 3D hydrogels for T cell expansion and differentiation
      Pérez del Río, E.; Santos, F.; Rodriguez, X. R.; Martínez-Miguel, M.; Roca-Pinilla, R.; Arís, A.; Garcia-Fruitós, E.; Veciana, J.; Spatz, J. P.; Ratera, I.; Guasch, J. Biomaterials 2020, 120313.
    1. Stable anchoring of bacteria-based protein nanoparticles for surface enhanced cell guidance
      Martínez-Miguel, M.; Kyvik, A. R.; M. Ernst, L.; Martínez-Moreno, A.; Cano-Garrido, O.; Garcia-Fruitós, E.; Vazquez, E.; Ventosa, N.; Guasch, J.; Veciana, J.; Villaverde, A.; Ratera, I. J. Mater. Chem. B 2020, 8 (23), 5080.

     

  • 2019

    1. High-Throughput Cell Motility Studies on Surface-Bound Protein Nanoparticles with Diverse Structural and Compositional Characteristics
      Tatkiewicz, W.; Seras-Franzoso, J.; García-Fruitós, E.; Vazquez, E.; Kyvik, A. R.; Ventosa, N.; Guasch, J.; Villaverde, A.; Veciana, J.; Ratera, I. ACS Biomater. Sci. Eng. 2019, 5 (10), 5470.
    1. Two-dimensional self-assembly and electrical properties of the donor-acceptor tetrathiafulvalene-polychlorotriphenylmethyl radical on graphite substrates
      Guasch, J.; Crivillers, N.; Souto, M.; Ratera, I.; Rovira, C.; Samorì, P.; Veciana, J. J. Appl. Phys. 2019, 125 (14), 142909.
    1. Cell Type-Dependent Integrin Distribution in Adhesion and Migration Responses on Protein-Coated Microgrooved Substrates
      Sales, A.; Ende, K.; Diemer, J.; Kyvik, A. R.; Veciana, J.; Ratera, I.; Kemkemer, R.; Spatz, J. P.; Guasch, J. ACS Omega 2019, 4 (1), 1791.
    1. Functionalization of polyacrylamide for nanotrapping positively charged biomolecules
      Davydova, N.; Rodriguez, X. R.; Blázquez, C.; Gómez, A.; Perevyazko, I.; Guasch, J.; Sergeev, V.; Laukhina, E.; Ratera, I.; Veciana, J. RSC Adv. 2019, 9 (27), 15402.

     

  • 2018

    1. Combining Adhesive Nanostructured Surfaces and Costimulatory Signals to Increase T Cell Activation
      Guasch, J.; Hoffmann, M.; Diemer, J.; Riahinezhad, H.; Neubauer, S.; Kessler, H.; Spatz, J. P. Nano Lett. 2018, 18 (9), 5899.
    1. Surface-Bound Gradient Deposition of Protein Nanoparticles for Cell Motility Studies
      Tatkiewicz, W. I.; Seras-Franzoso, J.; Garcia-Fruitós, E.; Vazquez, E.; Kyvik, A. R.; Guasch, J.; Villaverde, A.; Veciana, J.; Ratera, I. ACS Appl. Mater. Interfaces 2018, 10 (30), 25779.
    1. Artificial 3D Culture Systems for T Cell Expansion
      Pérez del Río, E.; Martinez Miguel, M.; Veciana, J.; Ratera, I.; Guasch, J. ACS Omega 2018, 3, 5273.
    1. Stimuli-Responsive Functionalization Strategies to Spatially and Temporally Control Surface Properties: Michael vs Diels–Alder Type Additions
      Kyvik, A. R.; Luque-Corredera, C.; Pulido, D.; Royo, M.; Veciana, J.; Guasch, J.; Ratera, I. J. Phys. Chem. B 2018, 122 (16), 4481.

  • 2017

    1. Integrin-Assisted T-Cell Activation on Nanostructured Hydrogels
      Guasch, J.; Muth, C. A.; Diemer, J.; Riahinezhad, H.; Spatz, J. P. Nano Lett. 2017, 17 (10), 6110.

     

  • 2016

    1. Synthesis of Binary Nanopatterns on Hydrogels for Initiating Cellular Responses
      Guasch, J.; Diemer, J.; Riahinezhad, H.; Neubauer, S.; Kessler, H.; Spatz, J. P. Chem. Mater. 2016, 28 (6), 1806.

  • 2015

    1. Segregation Versus Colocalization: Orthogonally Functionalized Binary Micropatterned Substrates Regulate the Molecular Distribution in Focal Adhesions
      Guasch, J.; Conings, B.; Neubauer, S.; Rechenmacher, F.; Ende, K.; Rolli, C. G.; Kappel, C.; Schaufler, V.; Micoulet, A.; Kessler, H.; Boyen, H.-G.; Cavalcanti-Adam, E. A.; Spatz, J. P. Adv. Mater. 2015, 27, 3737.

  • 2014

    1. Intramolecular electron transfer and charge delocalization in bistable donor–acceptor systems based on perchlorotriphenylmethyl radicals linked to ferrocene and tetrathiafulvalene units
      Souto, M.; Morales, D. C.; Guasch, J.; Ratera, I.; Rovira, C.; Painelli, A.; Veciana, J. J. Phys. Org. Chem. 2014, 27 (6), 465.

     

  • 2013

    1. Thermomagnetic Molecular System Based on TTF-PTM Radical: Switching the Spin and Charge Delocalization
      Souto, M.; Guasch, J.; Lloveras, V.; Mayorga, P.; Navarrete, J. T. L. e.; Casado, J.; Ratera, I.; Rovira, C.; Painelli, A.; Veciana, J. J. Phys. Chem. Lett. 2013, 4, 2721.
    1. A Molecular Toolkit for the Functionalization of Titanium‐Based Biomaterials That Selectively Control Integrin‐Mediated Cell Adhesion
      Rechenmacher, F.; Neubauer, S.; Mas-Moruno, C.; Dorfner, P. M.; Polleux, J.; Guasch, J.; Conings, B.; Boyen, H.-G.; Bochen, A.; Sobahi, T. R.; Burgkart, R.; Spatz, J. P.; Fässler, R.; Kessler, H. Chem. Eur. J. 2013, 19, 9218. 
    1. Intra-and Intermolecular Charge Transfer in Aggregates of Tetrathiafulvalene-Triphenylmethyl Radical Derivatives in Solution
      Guasch, J.; Grisanti, L.; Souto, M.; Lloveras, V.; Vidal-Gancedo, J.; Ratera, I.; Painelli, A.; Rovira, C.; Veciana, J. J. Am. Chem. Soc. 2013, 135, 6958. 
    1. Bistability of Fc-PTM-Based Dyads: The Role of the Donor Strength
      Guasch, J.; Grisanti, L.; Jung, S.; Morales, D.; D’Avino, G.; Souto, M.; Fontrodona, X.; Painelli, A.; Renz, F.; Ratera, I.; Veciana, J. Chem. Mater. 2013, 25, 808. 
    1. The perchlorotriphenylmethyl (PTM) radical
      Guasch, J.; Fontrodona, X.; Ratera, I.; Rovira, C.; Veciana, J. Acta Crystallogr. 2013, C69, 255.

     

  • 2012

    1. Induced Self‐Assembly of a Tetrathiafulvalene‐Based Open‐Shell Dyad through Intramolecular Electron Transfer
      Guasch, J.; Grisanti, L.; Lloveras, V.; Vidal-Gancedo, J.; Souto, M.; Morales, D. C.; Vilaseca, M.; Sissa, C.; Painelli, A.; Ratera, I.; Rovira, C.; Veciana, J. Angew. Chem. Int. Ed. 2012, 51, 11024.

     

  • 2011

    1. Electronic and Cytotoxic Properties of 2-Amino-naphtho[2,3-b]furan-4,9-diones
      Jiménez-Alonso, S.; Guasch, J.; Estévez-Braun, A.; Ratera, I.; Veciana, J.; Ravelo, A. G. J. Org. Chem. 2011, 76, 1634.

  • 2009

    1. Essential State Models for Solvatochromism in Donor− Acceptor Molecules: The Role of the Bridge
      Grisanti, L.; D’Avino, G.; Painelli, A.; Guasch, J.; Ratera, I.; Veciana, J. J. Phys. Chem. B 2009, 113 (14), 4718.
    1. Cooperativity from electrostatic interactions: understanding bistability in molecular crystals
      D’Avino, G.; Grisanti, L.; Painelli, A.; Guasch, J.; Ratera, I.; Veciana, J. CrystEngComm 2009, 11, 2040.

     

  • 2008

    1. Bistability in Fc-PTM crystals: The role of intermolecular electrostatic interactions
      D’Avino, G.; Grisanti, L.; Guasch, J.; Ratera, I.; Veciana, J.; Painelli, A. J. Am. Chem. Soc. 2008, 130, 12064.

     

  • 2006

    1. p-Nitrobenzyloxycarbonyl (pNZ) as an Alternative to Fmoc for the Protection of Amines in Solid-Phase Peptide Synthesis
      Isidro-Llobet, A.; Guasch-Camell, J.; Álvarez, M.; Albericio, F.. In Understanding Biology Using Peptides (Proceedings of the Nineteenth American Peptide Symposium), Blondelle, S. E., Ed. Springer: 2006; 116.

     

  • 2005

    1. p‐Nitrobenzyloxycarbonyl (pNZ) as a Temporary Nα‐Protecting Group in Orthogonal Solid‐Phase Peptide Synthesis–Avoiding Diketopiperazine and Aspartimide Formation
      Isidro-Llobet, A.; Guasch-Camell, J.; Álvarez, M.; Albericio, F. Eur. J. Org. Chem. 2005, 2005 (14), 3031.

Research

Research

Development of artificial extracellular matrices based on multifunctional 3D scaffolds for cancer (immuno)therapy

We develop different 3D synthetic and hybrid hydrogels to imitate extracellular matrices of different healthy and diseased tissues, especially from the immune system, with the objectives to 1) elucidate cancer- and immunotherapy-related cellular mechanisms, 2) improve immune cell cultures, and 3) develop novel patient-derived organoids, to have a positive influence on cancer (immuno)therapy and related disciplines.

  • Main publications

    1. F. Santos, J. Valderas-Rodríguez, E. Pérez del Río, M. Castellote-Borrell, X. Rodriguez Rodriguez, J. Veciana, I. Ratera, J. Guasch. Enhanced human T cell expansion with inverse opal hydrogels. Biomater. Sci., 2022 doi: 10.1039/d2bm00486k.
    2. E. Pérez del Río, F. Santos, X. Rodriguez Rodriguez, M. Martínez-Miguel, R. Roca-Pinilla, A. Arís, E. Garcia-Fruitós, J. Veciana, J. P. Spatz, I. Ratera, J. Guasch. CCL21-loaded 3D hydrogels for T cell expansion and differentiation. Biomaterials, 259 (2020) 120313.
    3. E. Pérez del Río, M. Martínez Miguel, J. Veciana, I. Ratera, J. Guasch. Artificial 3D Culture Systems for T Cell Expansion. ACS Omega, 3(5) (2018) 5273-5280.

  • Patent applications

    1. Guasch, J.; Ratera, I.; Veciana, J.; Santos, F.; Pérez del Río, E.; Castellote-Borrell, M. Inverse opal hydrogel and its use. EPO (EP22382293.3). Priority date 29/03/2022.
    2. Guasch, J.; Ratera, I.; Veciana, J.; Pérez del Río, E.; Santos, F.; Miguel, M. M.; Rodriguez, X. R.; Timoneda, M. Á. M.; Engel, E. A synthetic hydrogel and its use for immunotherapy and 3D-printing. PCT application (WO2021/234141 A1). Priority date 21/05/2020.

Design and fabrication of multifunctional 2D nanostructured surfaces for initiating immune cell responses related to cancer immunotherapy

We develop different functional 2D nanostructured surfaces on rigid substrates and hydrogels based on the block copolymer micellar lithography technique. These functional nanostructures are used to study the influence of different biomolecules and their cross-talk on (T) cell behavior.

Main publications

  1. A. Sales, K. Ende, J. Diemer, A. R. Kyvik, J. Veciana, I. Ratera, R. Kemkemer, J. P. Spatz, J. Guasch. Cell type-dependent integrin distribution in adhesion and migration responses on protein-coated microgrooved substrates. ACS Omega, 4 (2019) 1791-1800.
  2. J. Guasch, M. Hoffmann, J. Diemer, H. Riahinezhad, S. Neubauer, H. Kessler, J. P. Spatz. Combining Adhesive Nanostructured Surfaces and Costimulatory Signals to Increase T Cell Activation. Nano Lett., 18(9) (2018) 5899-5904.
  3. J. Guasch, C. Muth, J. Diemer, H. Riahinezhad, J. P. Spatz. Integrin-Assisted T-Cell Activation on Nanostructured Hydrogels. Nano Lett., 17(10) (2017) 6110-6116.

Read more …Research

People

People

Team Leader

Dr. Judith Guasch

CSIC Tenured Researcher and Group Leader of the Max Planck Partner Group

  • Miquel Castellote-Borrell

  • Adrián Rodríguez

  • Francesca Merlina

  • Xavier Rodríguez

    (in collaboration with Imma Ratera’s lab)

  • Sara Otín

  • Clàudia Torras

  • Somayeh Akhlaqi

  • Lara Yao Martorell

ALUMNI

  • Dr. Eduardo Pérez del Río (Collaborator)

  • Alba García, MSc

  • Tina Kraft

  • Dr. Marc Martínez-Miguel

  • Daniel Soriano, MSc

  • Perla Zazil Pérez, MSc

  • Dr. Fabião Santos

  • Roberto Martínez Soler, MSc

  • Julia Valderas, MSc

  • Emilia Schneider Revueltas, MSc

  • Gabriela Ávila Morales, MSc

Looking for MSc, PhD or postdoctoral positions?

We are always interested in highly skilled and motivated candidates looking for MSc, PhD or postdoctoral positions, with a background in materials science, chemistry, nanoscience and nanotechnology, biochemistry, biology, bioengineering, biomedicine and related fields. If you are interested in working with us, please send a motivation letter and your CV to: This email address is being protected from spambots. You need JavaScript enabled to view it.

This email address is being protected from spambots. You need JavaScript enabled to view it.

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