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Developing Patient-Derived Organoids as Cancer Models based on 3D Hydrogels

We are looking for MSc students to work on the synthesis and characterization of novel 3D hydrogels as extracellular matrices for the development of patient-derived tumoroids of different hematological and solid cancers. The internships can be funded through the competitive JAE Intro 2024 program (4200€ for 7 consecutive months) that is open until the 19th May! For more info check our CSIC's website: https://sede.csic.gob.es/intro2024

We are focused on the design and engineering of novel bionanomaterials to be used as artificial extracellular matrices (ECM) of tumoroids, i.e. tumor organoids. Our objective is to improve novel cancer (immuno)therapies and reduce animal experimentation in preclinical testing, thus lessening the implied ethical and economic burden, as well as decreasing the translation problems associated to variations among species.

In this project, the student will be involved in the synthesis and physicochemical characterization (NMR, X-ray tomography, rheology, SEM, confocal microscopy, etc.) of synthetic 3D hydrogels to act as artificial ECMs. He/she will also perform cell culture studies to evaluate the effectivity of such bionanomaterials, where different patient-derived tumors (hematological, pancreatic, lung, or colorectal tumors) will be used. The organoids will be analyzed by optical and fluorescence microscopy, ELISA, flow cytometry, etc. in collaboration with (pre)clinical settings such as IDIBAPS-Hospital Clinic de Barcelona and Vall d’Hebron Institute of Oncology (VHIO).

For more info check our CSIC's website: https://sede.csic.gob.es/intro2024 or contact Judith Guasch (This email address is being protected from spambots. You need JavaScript enabled to view it.)


 

MSc positions

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