The Max Planck Partner Group “Dynamic Biomimetics for Cancer Immunotherapy” led by Dr. Judith Guasch is established at the Institute of Materials Science of Barcelona (ICMAB-CSIC) in collaboration with the Max Planck Institute for Medical Research (Heidelberg, Germany).
The Partner Group is focused on the design, synthesis, and fabrication of bioinspired materials and the study of their interaction with cells for medical applications, especially those related to cancer immunotherapy.
Main scientific topics
Design of artificial extracellular matrices based on 3D scaffolds for cancer (immuno)therapy
We are currently developing different 3D synthetic and hybrid hydrogels to imitate extracellular matrices of different healthy and diseased tissues, especially from the immune system, with the objectives to 1) elucidate cancer- and immunotherapy-related cellular mechanisms, 2) improve immune cell cultures, and 3) develop novel patient-derived organoids, to have a positive influence on cancer (immuno)therapy and related disciplines.
Design and fabrication of multifunctional 2D nanostructured surfaces for initiating immune cell responses
We are currently developing different functional 2D nanostructured surfaces on rigid substrates and hydrogels based on the block copolymer micellar lithography technique. These functional nanostructures are used to study the influence of different biomolecules and their cross-talk on T cell behavior.